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Also, no proof suggests that CYP2D6 inhibition is helpful in managing codeine dependence,[23] while the metabolism of codeine to morphine (and for this reason further more metabolism to glucuronide morphine conjugates) does have an impact on the abuse possible of codeine.
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Injectable codeine is accessible for subcutaneous or intramuscular injection only; intravenous injection is contraindicated, as this can result in nonimmune mast-mobile degranulation and ensuing anaphylactoid response. Codeine suppositories are promoted in a few nations.
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The chance for serious respiration challenges is higher when You begin this medication and following a dose maximize, or if you are taking the incorrect dose/strength. Taking this medication with alcohol or other medications that could potentially cause drowsiness or breathing issues may perhaps cause really major Negative effects, like Dying. Also, other medicines can influence the removing of codeine out of your overall body, which can have an affect on how codeine works.
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